Product Description of Natamycin CAS#7681-93-8
Natamycin, alternatively named pimaricin, was first extracted from Streptomyces natalensis back in 1955. Its capacity against fungi greatly outperforms sorbic-acid. In June 1982, the US-FDA granted official permission for natamycin to be utilised as a food-grade preservative and marked it as a GRAS (Generally Recognized As Safe) ingredient.
This potent substance can restrain the reproduction of yeast, mould and other fungus species. It is adopted widely within the food-processing sector to hinder fungal proliferation. Safe for human ingestion, it will not alter the original taste of finished food. Around the globe, it is added into cheese, processed meat, baked pastries, fruit juice and numerous other food-stuff varieties.
It is manufactured via submerged-fermentation of Streptomyces natalensis, then subjected to sequential extraction and refinement procedures. The standard commercial blend contains 50% natamycin with the remaining 50% being lactose carrier.
Natamycin Chemical Properties
| Melting point | 2000C (dec) |
| alpha | D20 +278° (c = 1 in CH3COOH) |
| Boiling point | 952℃ |
| density | 1.0 g/mL at 20 °C(lit.) |
| refractive index | 1.5960 (estimate) |
| Fp | >110°(230°F) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Soluble in DMSO |
| form | aqueous suspension |
| pka | pKa 4.6(50% aq. MeOEtOH) (Uncertain);8.35 (Uncertain) |
| color | Cream colored |
| Water Solubility | 0.41g/L(21 ºC) |
| Sensitive | Light Sensitive |
| Merck | 136453 |
| BRN | 1614878 |
| Stability: | Light sensitive |
| InChIKey | NCXMLFZGDNKEPB-FFPOYIOWSA-N |
| LogP | 0.880 (est) |
| EPA Substance Registry System | 6,11,28-Trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid, 22-[(3-amino-3,6-dideoxy-.beta.-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-, (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)- (7681-93-8) |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 24/25-36 |
| WGK Germany | 2 |
| RTECS | TK3325000 |
| F | 46244 |
| HS Code | 29419090 |
| Toxicity | LD50 orally in male, female rats (g/kg): 2.73, 4.67 (Levinskas) |
Product Applications of Natamycin CAS#7681-93-8
Natamycin serves as a powerful anti-mould preservative. Once handled with its aqueous suspension by spraying or dipping the air-exposed food surfaces prone to mould contamination, it delivers outstanding fungus-resistant protection.
For fermented-cheese processing, it selectively holds back mould proliferation while permitting beneficial microbes to grow and metabolize normally.
For proper preservation, the product needs storing inside well-sealed packaging, kept away from direct sunlight and maintained below 15 °C.
