6-Chloroimidazo [1,2-b] pyridazine-2-carboxylic Acid CAS#14714-24-0

Product Description of 6-Chloroimidazo[1,2-b]pyridazine-2-carboxylic Acid CAS#14714-24-0

6-Chloroimidazo[1,2-b]pyridazine-2-carboxylic acid is a fused nitrogen-containing heterocyclic compound with the molecular formula C₇H₄ClN₃O₂ and a molecular weight of 197.578. It appears as a beige-colored solid at room temperature, featuring a melting point of about 248 °C. This compound is sparingly soluble in water and dissolves well in polar organic solvents such as DMSO and DMF. 

The integrated chloro and carboxyl functional groups bring favorable chemical reactivity, making it a valuable heterocyclic building-block intermediate. Proper cold-condition sealed storage under inert atmosphere is required to maintain its chemical stability and product purity.

6-Chloroimidazo[1,2-b]pyridazine-2-carboxylic Acid Chemical Properties

Product Application of 6-Chloroimidazo[1,2-b]pyridazine-2-carboxylic Acid CAS#14714-24-0

6-Chloroimidazo[1,2-b]pyridazine-2-carboxylic acid serves as a valuable heterocyclic building-block intermediate for pharmaceutical-active molecule synthesis, especially Trk antagonists. It participates in constructing molecular frameworks that suppress intracellular kinase activity of TrkA and other Trk receptor subtypes.

 Tropomyosin receptor kinases are receptor tyrosine kinases triggered by neurotrophic factors, which take part in biological pathways related to pain signal transmission and tumor proliferation. Derivatives synthesized from this intermediate can be developed into targeted drug candidates, showing promising research prospects for analgesic and anti-cancer therapies in pre-clinical pharmaceutical development.