Polyethylene-Polypropylene Glycol CAS#9003-11-6
Polyethylene-Polypropylene Glycol, also named Poloxamer, is a triblock nonionic polyether copolymer consisting of hydrophilic polyoxyethylene segments and hydrophobic polyoxypropylene segments. It appears as white waxy granules or colorless to pale yellow viscous liquid, nearly odorless. It is freely miscible with cold water, ethanol and many organic solvents.
This polymer features unique reverse thermal gelation behavior, with pH value ranging from 5.0 to 7.5 in aqueous solution. It has low toxicity and excellent biocompatibility. Different grades with varied molecular weights are available to meet different formulation requirements. Widely used as surfactant, solubilizer and pharmaceutical excipient.
Polyethylene-polypropylene Glycol Chemical Properties
| Melting point | 57-61 °C |
| Boiling point | >200 °C(lit.) |
| bulk density | 1050kg/m3 |
| density | 1.095 g/mL at 25 °C |
| vapor density | >1 (vs air) |
| vapor pressure | <0.3 mm Hg ( 20 °C) |
| refractive index | n20/D 1.466 |
| Fp | >230 °F |
| storage temp. | 2-8°C |
| solubility | H2O: at <70 °Csoluble |
| form | solution |
| color | APHA: ≤120, 50/50 in CH3OH |
| PH | 5.0-7.5 (100g/L in H2O) |
| PH Range | 5.0 - 7.5 |
| biological source | synthetic |
| Water Solubility | Miscible with water. |
| λmax | λ: 260 nm Amax: ≤0.3 |
| λ: 280 nm Amax: ≤0..2 | |
| Merck | 137644 |
| Hydrophilic-Lipophilic Balance (HLB) | 18 - 23 |
| Cosmetics Ingredients Functions | SURFACTANT - CLEANSING |
| SURFACTANT - HYDROTROPE | |
| CLEANSING | |
| SOLVENT | |
| HUMECTANT | |
| EMULSION STABILISING | |
| BINDING | |
| SURFACTANT - EMULSIFYING | |
| VISCOSITY CONTROLLING | |
| InChI | 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2 |
| InChIKey | RVGRUAULSDPKGF-UHFFFAOYSA-N |
| SMILES | O2C(C2)C.O1CC1 |
| LogP | -1.293 (est) |
| EPA Substance Registry System | Poloxalene (9003-11-6) |
Safety Information
| Hazard Codes | T |
| Risk Statements | 21-23/24/25-25-36/37/38 |
| Safety Statements | 23-24/25-45-36/37/39-26 |
| WGK Germany | 3 |
| RTECS | TP6164333 |
| TSCA | TSCA listed |
| HS Code | 39059100 |
| Storage Class | 11 - Combustible Solids |
| Hazardous Substances Data | 9003-11-6(Hazardous Substances Data) |
| Toxicity | LD50 oral in rabbit: 35gm/kg |
Product Application of Polyethylene-Polypropylene Glycol CAS#9003-11-6
Polyethylene-Polypropylene Glycol (Poloxamer) is a versatile nonionic block copolymer widely applied across pharmaceutical, cosmetic and industrial fields.
In pharmaceutical manufacturing, it functions as a multi-functional excipient, acting as solubilizer, emulsifier and sustained-release gelling agent for oral suspensions, topical gels and suppositories. It improves the solubility and bioavailability of poorly soluble active drug ingredients. In personal care products, it serves as emulsifier and wetting agent to stabilize creams and lotions.
For industrial usage, it works as dispersant and defoamer in coatings, textile printing and dyeing, and cleaning formulations. With adjustable molecular grades, it can be tailored for lab research, cosmetic formulation, pharmaceutical production and various fine chemical processing systems.
